Unique Features

  • Manual Microscopy is the reference method (not flow cytometry) for urine sediment analysis - True automation of the "Gold Standard" manual microscopy.
  • Large (13.3') high resolution touch screen gives real view of microscopic images - Truly similar with HPF images of manual microscopy.
  • In-built high-definition CCD cameras will capture images and artificial intelligence (AI) will identify, count and tag all particles - Truly independent.
  • No need for repetition of sample with manual microscopy, which includes manual slide preparation - Truly fully automatic.
  • Cuvette is the only consumable, no need of additional reagents - Truly cost effective.

Manual Microscopy

  • Manual microscopy is a time-consuming process

 - Approx. 10 - 12 minutes per sample

 - Takes too much time of "highly qualified" lab personnel

  • Maximum risk of errors

 - Sample preparation

 - Slide preparation

 - Slide viewing

  • Doubt in quality of reports

 - Abnormal findings are always questionable


Automated Urine Microscopy

  • Automated microscopy saves time

 - Approx. 1 ½ minutes per sample

  • Full traceability of results

 - > 25000 images of patient's results can be stored & shared

 - Possible to review and verify results

  • Standardized measurement process

 - Process security


S50 - Simple to Run Samples

  • Just one click to start
  • Fully auto measurement process

 1. Put urine sample at sample holder

 2. Click on start button

 3. Results on the screen along with microscopic images


S50 - Instrument Measuring Sequence

  • Urine sample is homogenized in the test tube
  • Sample is aspirated from test tube and injected into disposable cuvette

Centrifugation is performed to create a monolayer of particles at bottom of the cuvette

  • Images are taken by built-in CCD
  • AI (Computer Vision + Machine Learning) evaluation marks the particles and calculates results
  • Display results along with images

Used cuvette is placed into waste-bin

S50 - Instrument Measuring Sequence


sample injection into cuvette


accelerated sedimentation, auto-focusing


AI automatic recognition


Measurement Technology

  • Measurement (Fully Automatic)

 - Sample preparation

 - Sedimentation

 - Microscopy : focusing, image capturing

  • Image Evaluation (Fully Automatic)

 - Particle recognition

 - Particle classification

 - Particle labelling

  • Result Calculation (Fully Automatic)

 - Summarizing the detected particles

 - Unit conversion

 - Semi-quantitative categorization

Measurement Technology - Sample Preparation

  • Put urine sample in to sample holder

 - S50 is equipped with in-built barcode reader

 - Bi-directional LIS / HIS

  • Stainless steel probe for transfer of urine

 - Mix urine before aspiration

 - Probe wash after each transfer of liquid


Measurement Technology - Patented Cuvette

  • Patented cuvette and distilled water are the only consumables
  • One sample, one cuvette

 - Each sample is analyzed in a separate cuvette

 - No carry over between samples


Measurement Technology - Sedimentation

  • Centrifugation is performed at an acceleration level of 260G

 - Centrifugation @ 2000 RPM, for 10 seconds

 - Create monolayer of particles at the bottom of the cuvette

 - Drive all particles to the same level to achieve good focusing

 - Better pictures based on good focusing


Measurement Technology - Microscopy

  • Microscope with CCD to create whole view field images

 - Multiple digital images are taken by CCD

 - Possible to chose 5, 10, 15 or 20 images per sample (default setting is 15)

 - Images and results are displayed, rechecked as well as corrected


Measurement Technology - Artificial Intelligence

  • How Artificial Intelligence works in S50

 - S50 works on deep learning algorithm

 - Algorithm of S50 need 3000 marked pictures

 - Take pictures of thousands of samples

 - Marked the name of particle in picture by morphologist, i.e. RBC, WBC . . .

 - Different cells have different physical properties
 ・ Shape, Size, Diameter & Thickness

 - It takes these physical properties, models them, and trains them to forms algorithm of S50


Result Display - Screen Shots


Report Printing

Automatic Label


Manual Label

  • Other particles visible in image can be marked manually
  • RBC subclasses
  • Separation of renal and superficial / deep transitional epithelial cells
  • Pathological cast subtypes
  • Additional crystal subtype categories (CaPh; CYS; LEU; Amorphous Crystals)
  • Spermatozoon
  • Lipids
  • Protozoa (Trichomonas Vaginalis, Balantidium Coli)
  • Parasites (Schistosoma Haematobium, Enterobius Vermicularis)

iCLINICAL Cloud Service

  • S50 instruments can be connected to its own cloud platform -- ""
  • A professional and technical service platform that provides medical practitioners

 - Online training

 - Online help

 - Online sharing

 - Knowledge management

 - Access to historical data analysis and research


Test Performance Data

  • Accuracy

 - Coincidence rate of identification (versus manual microscopy)

 - Red Blood Cell ≥ 98%, White Blood Cell ≥ 96%, Tubular ≥ 72%

 - The false negative rate of analyzer (versus manual microscopy) is zero

  • Repeatability

 - When the cell concentration is 50 / uL, CV ≤ 18%

 - When the cell concentration is 200 / uL, CV ≤ 11%

  • Stability

 - CV of total cell count results is ≤ 14%

Test Performance Data

  • Carryover rate is zero
  • Background counting

 - The analyzer's blank count for WBC and RBC is zero

  • Limit of Detection (compare to manual microscopy)

 - S50 analyzer can detect RBC / WBC samples with concentration level of 5 / ul

S50 - Salient Features

  • High throughput - 50 sediment analysis per hour
  • Accurate and reliable results - Automation of gold standard method
  • Reduced workload - direct measurement
  • Standardized method - no influence of individual preparing slide or interpreting results
  • Traceable results - results and images can be reviewed again at any time
  • Automated result generation - transmission errors are avoided
  • Displaying of whole view field image in large 13.3' touch screen
  • No repetition of sample with manual microscopy
  • Only one consumable (cuvette) is needed